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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DENND1C
All Species:
9.7
Human Site:
Y452
Identified Species:
23.7
UniProt:
Q8IV53
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IV53
NP_079174.2
801
87065
Y452
Q
P
A
V
K
N
M
Y
R
S
A
K
S
G
L
Chimpanzee
Pan troglodytes
XP_001138488
775
86507
K452
R
T
A
Y
K
F
A
K
N
H
A
K
L
G
L
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_542137
887
96006
Y537
Q
P
A
V
K
N
M
Y
R
S
A
K
S
G
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8CFK6
786
86671
A464
D
S
L
Q
E
Y
C
A
S
K
A
K
S
G
L
Rat
Rattus norvegicus
NP_001119761
546
59730
N225
S
G
L
K
G
M
Q
N
L
L
M
I
K
D
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517017
914
100669
Y574
Q
P
A
V
K
N
M
Y
R
S
A
K
S
G
L
Chicken
Gallus gallus
XP_422194
839
93195
K505
K
T
A
Y
K
F
A
K
N
H
A
R
Q
G
I
Frog
Xenopus laevis
Q68F67
1010
112359
K436
K
F
A
K
D
H
A
K
M
G
I
K
E
V
K
Zebra Danio
Brachydanio rerio
Q6NXD8
1311
147682
P877
T
E
S
S
V
G
L
P
G
L
R
V
S
V
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_397549
694
78747
S374
E
R
L
N
M
L
N
S
G
L
G
F
S
D
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
36.7
N.A.
73.5
N.A.
70.6
45.4
N.A.
51.3
37.4
34.9
20.2
N.A.
N.A.
32.5
N.A.
N.A.
Protein Similarity:
100
52.8
N.A.
77.7
N.A.
78.2
52
N.A.
62.4
53.6
49.1
32.1
N.A.
N.A.
50.1
N.A.
N.A.
P-Site Identity:
100
40
N.A.
100
N.A.
33.3
0
N.A.
100
26.6
13.3
6.6
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
100
46.6
N.A.
100
N.A.
40
0
N.A.
100
46.6
26.6
26.6
N.A.
N.A.
13.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
60
0
0
0
30
10
0
0
60
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
0
0
10
0
0
0
0
0
0
0
0
20
0
% D
% Glu:
10
10
0
0
10
0
0
0
0
0
0
0
10
0
10
% E
% Phe:
0
10
0
0
0
20
0
0
0
0
0
10
0
0
0
% F
% Gly:
0
10
0
0
10
10
0
0
20
10
10
0
0
60
10
% G
% His:
0
0
0
0
0
10
0
0
0
20
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
10
10
0
0
20
% I
% Lys:
20
0
0
20
50
0
0
30
0
10
0
60
10
0
10
% K
% Leu:
0
0
30
0
0
10
10
0
10
30
0
0
10
0
50
% L
% Met:
0
0
0
0
10
10
30
0
10
0
10
0
0
0
0
% M
% Asn:
0
0
0
10
0
30
10
10
20
0
0
0
0
0
0
% N
% Pro:
0
30
0
0
0
0
0
10
0
0
0
0
0
0
0
% P
% Gln:
30
0
0
10
0
0
10
0
0
0
0
0
10
0
0
% Q
% Arg:
10
10
0
0
0
0
0
0
30
0
10
10
0
0
0
% R
% Ser:
10
10
10
10
0
0
0
10
10
30
0
0
60
0
0
% S
% Thr:
10
20
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
30
10
0
0
0
0
0
0
10
0
20
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
20
0
10
0
30
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _